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中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (9): 1023-1026.

• 基础研究 • 上一篇    下一篇

复方海蛇胶囊对帕金森病小鼠的作用

沈熊1, 马海滨2, 厉璐帆2, 李秀敏2, 宋宇2, 张旭东1, 马世平2   

  1. 1浙江杭康药业有限公司,杭州 310018,浙江;
    2中国药科大学中药药理教研室,南京 210009,江苏
  • 收稿日期:2010-06-09 修回日期:2010-07-24 出版日期:2010-09-26 发布日期:2020-09-17
  • 通讯作者: 马世平,男,教授,博士生导师,研究方向:中药及复方神经药理学研究。Tel: 025-83271507, E-mail: shipingma@hotmail.com
  • 作者简介:沈熊,男,硕士,研究方向:中成药研究与开发。Tel: 0571-86857599, E-mail: shxi@vip.163.com

Effects of Sea Cucumber Capsule on the Parkinson's mouse induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine

SHEN Xiong1, MA Hai-bin2, LI Lu-fan2, LI Xiu-min2, SONG Yu2, ZHANG Xu-dong1, MA Shi-ping2   

  1. 1Zhejiang HACON Pharmaceutical Co., Ltd, Hangzhou 310018, Zhejiang, China;
    2Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
  • Received:2010-06-09 Revised:2010-07-24 Online:2010-09-26 Published:2020-09-17

摘要: 目的: 研究复方海蛇胶囊对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的帕金森病小鼠的作用。方法: 采用C57BL/6J小鼠腹腔注射MPTP制备帕金森病动物模型,给药14 d后观察各组小鼠行为活动变化,利用高效液相-电化学检测器检测纹状体内多巴胺 ( DA ) 及其代谢产物二羟基苯乙酸 ( DOPAC ) 和高香草酸 ( HVA ) 等的含量变化。结果: 复方海蛇胶囊可以显著对抗MPTP对黑质及纹状体的损伤作用,明显改善帕金森病的症状;与模型组相比,复方海蛇胶囊治疗后可以显著提高小鼠纹状体内DA、DOPAC和 HVA的含量(P<0.01)。结论: 复方海蛇胶囊通过保护多巴胺能神经元,提高纹状体内DA的含量,改善帕金森病的症状。

关键词: 帕金森病, 复方海蛇胶囊, MPTP, 神经保护作用, 神经递质

Abstract: AIM: To investigate the effect of Sea Cucumber Capsule on the Parkinson's mouse induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP).METHODS: C57BL/6J mice were treated intraperitoneally with MPTP to prepare the PD model. The mice were treated with different doses Sea Cucumber Capsule for 14 days. The behavior tests of mice were observed and the contents of DA and its metabolites in the striatum of each group mice were detected by high performance liquid chromatography with electrochemical detection (HPLC-ECD).RESULTS: Sea Cucumber Capsule obviously enhanced the model mice's capability of motor coordination and prevented the destructive effect of MPTP. Sea Cucumber Capsule was effective against MPTP-induced neurodegeneration of the nigrostriatal dopaminergic neural pathway, and increasing DA and its metabolites' levels in the striatum.CONCLUSION: This study proves that Sea Cucumber Capsule could ameliorate the typical symptom of PD by protecting dopaminergic system.

Key words: Parkinson's disease, Sea Cucumber Capsule, MPTP

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