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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (2): 147-149.

• 临床研究 • 上一篇    下一篇

胃癌体外化疗药物敏感性及临床疗效研究

辛华雯, 吴笑春, 李罄, 贾菊风1, 杜光祖1   

  1. 广州军区武汉总医院临床药理科,1肿瘤血液科, 武汉 430070
  • 收稿日期:2001-11-21 修回日期:2001-12-15 出版日期:2002-04-26 发布日期:2020-11-27
  • 通讯作者: 辛华雯, 女, 博士, 副主任医师, 从事肿瘤药理学及临床药理学研究。Tel:027-87879797-78481 E-mail:hwxin@public.wh.hb.cn

Study of chemosensitivity in vitro and therapeutic effects of chemotherapy on stomach cancer

XIN Hua-Wen, WU Xiao-Chun, LI Qing, JIA Ju-Feng1, DU Guang-Zu1   

  1. Department of Clinical Pharmacology,1Department of Oncology and Hematology, Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070
  • Received:2001-11-21 Revised:2001-12-15 Online:2002-04-26 Published:2020-11-27

摘要: 目的: 研究胃癌体外化疗药物敏感性与临床疗效的关系, 为临床肿瘤化疗个体化提供依据。方法: 用改进的MTT 法测定 98 例胃癌组织的化疗药物敏感性, 并依药敏结果选择化疗方案, 观察临床近期疗效和远期生存率。 结果: 98 例胃癌组织对 8 种化疗药物的敏感顺序为顺铂、丝裂霉素、阿霉素、鬼臼乙甙、5-氟脲嘧啶、阿糖胞苷、长春新碱、氨甲喋呤, 与临床实践证明的对胃癌有效的单药基本一致。 体外敏感性与临床近期疗效的总符合率为 81.8%(18/22), 药敏试验组的 3 年生存率及 Ⅱ、Ⅲ期胃癌患者的5 年生存率分别为 62.5%、52.8 %, 明显高于按经验给药组(P<0.05)。 结论: 按体外药敏试验结果指导化疗可提高胃癌患者尤其是中晚期患者的远期存活率。

关键词: MTT 法, 胃癌, 化疗, 药敏试验

Abstract: AIM: To study chemosensitivity in vitro and therapeutic effects of chemotherapy in the patients with stomach cancer.METHODS: Chemosensitivity in vitro of 98 cases with gastric cancer was determined by modified MTT method and chemotheraputic regimen was selected according to the results of chemosensitivity. Therapeutic effects on gastric cancer for the shot term and long term were studied.RESULTS: The chemosensitivity order of drugs in 98 cases with gastric cancer was cis-platin, mitomycin, doxorubicin, etoposide, fluorouracil, cytarabine, vincristin, and methotrexate, andwas consis-tent with effective drugs for gastric cancer proved by clini-cal practice.The total coincidence rate of chemosensitivi-ty in vitro and therapeutic effects for short term was 81.8%(18/22).The survival rate of three years and of five years for Ⅱ, Ⅲ phase gastric cancer in chemosensi-tivity test group were 62.5% and 52.8%, respectively, which were higher than those in control group. CONCLUSION: Chemotherapy under the guidance of chemosensitivity in vitro can improve the long term sur-vival rate of gastric cancer, especially advanced gastric cancer.

Key words: MTT assay, gastric cancer, chemother-apy, chemosensitivity

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