关键词: 司帕沙星, 药代动力学, 肾功能, 高效液相色谱法

Abstract: Aim To observe pharmaco kinetics of sparfloxacin in the patients with abnormal kidney function.Methods Sparfloxacin concent ration in serum and urine of ten patients were measured by a reversed phase high performance liquid chromatography method after having a single dose and multiple dose of 200 mg sparfloxacin tablet.The Pharmacokinetics parameters were computed with program PKBP-N₁.Results The main pharmacokinetics parameters at single dose of sparfloxacin were T_1/2(ka) =(1.02±0.22)h, T_1/2(β)=(15.73±3.20)h, T_peak =(3.88±0.75)h, C_max =(0.59±0.17)mg·L^-1 and AUC_0-∞=(11.25±2.13)mg·h·L^-1, while at multiple dose were T_1/2(ka)=(1.25±0.27)h, T_1/2(β)=(16.90±4.13)h, T_peak =(4.18±0.78)h, C_max =(0.79±0.21)mg·L^-1 and AUC_0-∞=(13.34±2.25)mg·h·L^-1.The discharge rate in 24h of original sparfloxacin in urine were (10.58±1.47)% and (11.08±1.94)% separately.C_max and AUC in multiple dose were marked higher than in single dose(P<0.05).The retainfactor was 1.19. Conclusion The pharmacokinetics parameters of sparfloxacin are not signi ficantly changed in patients with middle-abnormal kidney function had not change.

Key words: sparfloxacin, pharmaco kinetics, kidney function, high performance liquid chromatography