内源性致幻剂在心力衰竭合并抑郁中的研究进展

doi:10.12092/j.issn.1009-2501.2026.02.015

中国临床药理学与治疗学 ›› 2026, Vol. 31 ›› Issue (2): 272-280.doi: 10.12092/j.issn.1009-2501.2026.02.015

内源性致幻剂在心力衰竭合并抑郁中的研究进展

史芊元¹(), 黄凯¹, 张浥¹, 端家豪¹, 杨春², 杨玲¹^,³^,*()

1. 苏州大学附属第三医院心血管内科，常州 213003，江苏
2. 南京医科大学第一附属医院麻醉与围术期医学科，南京 210029，江苏
3. 常州市第一人民医院心血管内科，常州 213003，江苏

收稿日期:2025-06-13 修回日期:2025-10-01 出版日期:2026-02-26 发布日期:2026-03-17
通讯作者: 杨玲 E-mail:1329126248@qq.com;linda_yl@sina.com
作者简介:史芊元，女，在读研究生，研究方向：心血管疾病合并抑郁。E-mail：1329126248@qq.com
基金资助:
国家自然科学基金项目（82070405；82271254）；江苏省自然科学基金项目（BK20240054）；江苏省创新创业团队项目（JSSCTD202144）；常州市“十四五”卫生健康高层次人才培养工程—领军人才（2022260）；常州市医学重点学科：心血管病学（CZXK202202）；常州市卫生健康委青年人才科技项目（QN202351）；常州市科技计划应用基础研究（CJ20245006）

Role of endogenous hallucinogens in heart failure comorbid with depression

Qianyuan SHI¹(), Kai HUANG¹, Yi ZHANG¹, Jiahao DUAN¹, Chun YANG², Ling YANG¹^,³^,*()

1. The Third Affiliated Hospital to Soochow University, Changzhou 213003, Jiangsu, China
2. The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China
3. The First People’s Hospital of Changzhou, Changzhou 213003, Jiangsu, China

Received:2025-06-13 Revised:2025-10-01 Online:2026-02-26 Published:2026-03-17
Contact: Ling YANG E-mail:1329126248@qq.com;linda_yl@sina.com

摘要/Abstract

摘要：

随着全球人口老龄化的加剧，心力衰竭合并抑郁的发病率不断升高，造成了健康和经济负担。内源性致幻剂是一类可以在体内产生致幻作用的化合物，近年来引起了学术界的广泛关注，已有研究证实其对神经系统疾病、冠心病、肺纤维化以及抗肿瘤活性有影响。然而，内源性致幻剂在心衰合并抑郁中的作用机制仍不清楚。本文从调节神经-内分泌网络、改变神经可塑性、调节免疫炎症系统、减少氧化应激和细胞凋亡4个方面介绍其潜在机制。这些见解旨在为心力衰竭合并抑郁患者提供治疗靶点和基础研究方向，最终改善患者预后和生活质量。

关键词: 致幻剂, 心力衰竭, 抑郁, 内源性大麻素, N,N-二甲基色胺

Abstract:

With the growing global aging population, the incidence of heart failure complicated with depression is increasing, which causes a heavy health and economic burden. In recent years, endogenous hallucinogens, a class of compounds that can produce hallucinogenic effects in the body, have garnered widespread attention in the academic community, as previous studies have confirmed their effects on nervous system diseases, coronary heart disease, pulmonary fibrosis, and anti-tumor activity. However, the mechanisms of action of endogenous hallucinogens in the context of heart failure with depression remain unclear. This review introduces the potential mechanisms from four aspects: regulating the neuro-endocrine network, altering neuroplasticity, modulating the immune-inflammatory system, and reducing oxidative stress and apoptosis. These insights aim to provide therapeutic targets and basic research directions for patients with heart failure complicated with depression, ultimately improving the prognosis and quality of life of these patients.

Key words: hallucinogens, heart failure, depression, endocannabinoids, N,N-dimethyltryptamine

中图分类号:

史芊元, 黄凯, 张浥, 端家豪, 杨春, 杨玲. 内源性致幻剂在心力衰竭合并抑郁中的研究进展[J]. 中国临床药理学与治疗学, 2026, 31(2): 272-280.

Qianyuan SHI, Kai HUANG, Yi ZHANG, Jiahao DUAN, Chun YANG, Ling YANG. Role of endogenous hallucinogens in heart failure comorbid with depression[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(2): 272-280.

图/表 1

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分类	调节神经内分泌网络	调节神经可塑性	调节免疫炎症系统	减少氧化应激与细胞凋亡
色胺衍生物	能与5-HT受体、DA受体、NE受体、TAARs、 5-HT转运体、单胺氧化酶及Sig-1R结合；在体内急性转化为儿茶酚胺类物质；促进5-HT释放，抑制 5-HT与DA再摄取。	作为成人NSC活性的关键调节因子，调节SGZ干细胞群的增殖与分化；使小鼠新生神经元树突结构更复杂；刺激5-HT2受体，增强BDNF的表达。	NFAT和NF-kB通路激活，下调toll样受体和G蛋白偶联受体的表达；作为IDO的非竞争性抑制剂，显著抑制炎性细胞因子分泌；抑制CD4+T辅助细胞向炎性Th1和Th17极化；上调抗炎因子IL-10的mRNA和蛋白表达；作为内源性调节因子。	降低APAF1的mRNA表达；降低IL-1β、IL-6与TNF-α水平；提高抗炎因子IL-10浓度；减轻人皮质神经元及moMACs和moDCs的氧化应激；脂质过氧化标志物TBARS下降，SOD活性升高。
内源性大麻素	抑制钙通道、促进钾通道开放，减少Ach、NE、谷氨酸释放；在VTA区解除GABA对DA神经元的抑制；在NAc区抑制皮层谷氨酸对CINs影响；调节DRN中GABA能神经元；激活膜相关GR。	局部诱导LTP、远端诱导LTD，促进周围突触的LTP形成；依赖Ca²⁺浓度增加介导DSI和DSE；介导海马体与NAc中TRPV受体诱导LTD。	降低血清TNF-α；减少心肌炎症标志物；减少血管炎症标志物；减少CD45+白细胞数量。	上调抗氧化酶血红素加氧酶- 1 mRNA；提升肌球蛋白重链比率；增强CCL2 mRNA表达；减少ROS、MDA和MPO生成；促进SOD合成。

分类	调节神经内分泌网络	调节神经可塑性	调节免疫炎症系统	减少氧化应激与细胞凋亡
色胺衍生物	能与5-HT受体、DA受体、NE受体、TAARs、 5-HT转运体、单胺氧化酶及Sig-1R结合；在体内急性转化为儿茶酚胺类物质；促进5-HT释放，抑制 5-HT与DA再摄取。	作为成人NSC活性的关键调节因子，调节SGZ干细胞群的增殖与分化；使小鼠新生神经元树突结构更复杂；刺激5-HT2受体，增强BDNF的表达。	NFAT和NF-kB通路激活，下调toll样受体和G蛋白偶联受体的表达；作为IDO的非竞争性抑制剂，显著抑制炎性细胞因子分泌；抑制CD4+T辅助细胞向炎性Th1和Th17极化；上调抗炎因子IL-10的mRNA和蛋白表达；作为内源性调节因子。	降低APAF1的mRNA表达；降低IL-1β、IL-6与TNF-α水平；提高抗炎因子IL-10浓度；减轻人皮质神经元及moMACs和moDCs的氧化应激；脂质过氧化标志物TBARS下降，SOD活性升高。
内源性大麻素	抑制钙通道、促进钾通道开放，减少Ach、NE、谷氨酸释放；在VTA区解除GABA对DA神经元的抑制；在NAc区抑制皮层谷氨酸对CINs影响；调节DRN中GABA能神经元；激活膜相关GR。	局部诱导LTP、远端诱导LTD，促进周围突触的LTP形成；依赖Ca²⁺浓度增加介导DSI和DSE；介导海马体与NAc中TRPV受体诱导LTD。	降低血清TNF-α；减少心肌炎症标志物；减少血管炎症标志物；减少CD45+白细胞数量。	上调抗氧化酶血红素加氧酶- 1 mRNA；提升肌球蛋白重链比率；增强CCL2 mRNA表达；减少ROS、MDA和MPO生成；促进SOD合成。

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内源性致幻剂在心力衰竭合并抑郁中的研究进展

Role of endogenous hallucinogens in heart failure comorbid with depression

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