糖尿病微血管病变中的细胞衰老及治疗药物研究进展

doi:10.12092/j.issn.1009-2501.2026.04.010

中国临床药理学与治疗学 ›› 2026, Vol. 31 ›› Issue (4): 509-516.doi: 10.12092/j.issn.1009-2501.2026.04.010

糖尿病微血管病变中的细胞衰老及治疗药物研究进展

李金菊¹(), 杨浩², 阮诺冰¹, 许奇¹, 毕正¹, 李瑜璠¹, 王帆竞¹, 林逸轩³, 方朝晖³^,⁴^,*()

1. 安徽中医药大学第一临床医学院，合肥 230031，安徽
2. 安徽中医药大学第二附属医院老年病科，合肥 230061，安徽
3. 安徽中医药大学第一附属医院内分泌科，合肥 230031，安徽
4. 合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所，合肥 230031，安徽

收稿日期:2024-10-18 修回日期:2024-11-15 出版日期:2026-04-26 发布日期:2026-04-30
通讯作者: 方朝晖 E-mail:2677161385@qq.com;fangzhaohui9097@163.com
作者简介:李金菊，女，博士研究生，从事中医药防治内分泌代谢病研究。E-mail：2677161385@qq.com
基金资助:
国家自然科学基金（82174153）；合肥综合性国家科学中心大健康研究院“揭榜挂帅”项目（2023CXMMTCM003）；安徽省高校科研项目（2023AH050867）

Research progress on cellular senescence and therapeutic drugs in diabetic microvascular complications

Jinju LI¹(), Hao YANG², Nuobing RUAN¹, Qi XU¹, Zheng BI¹, Yufan LI¹, Fanjing WANG¹, Yixuan LIN³, Zhaohui FANG³^,⁴^,*()

1. The First Clinical Medical College of Anhui University of Traditional Chinese Medicine, Hefei 230031, Anhui, China
2. Department of Geriatrics, The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230061, Anhui, China
3. Department of Endocrinology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031, Anhui, China
4. Institute of Xin'an Medicine and Modernisation of Traditional Chinese Medicine, Hefei Comprehensive National Science Centre, Hefei230031, Anhui, China

Received:2024-10-18 Revised:2024-11-15 Online:2026-04-26 Published:2026-04-30
Contact: Zhaohui FANG E-mail:2677161385@qq.com;fangzhaohui9097@163.com

摘要/Abstract

摘要：

糖尿病微血管病变是糖尿病最早出现且最常见的并发症，其特征是微血管内皮功能受损、基底膜增厚和微血栓形成，累及肾脏、视网膜和神经，也是导致患者生活质量下降和预期寿命缩短的关键因素。近年来的临床及实验研究发现，细胞衰老是该类疾病的主要危险因素。细胞衰老是一种不可逆的细胞周期停滞状态，参与多种生理病理过程影响糖尿病微血管病变的发生发展。本文就细胞衰老在糖尿病微血管病变进程中的作用机制及目前靶向细胞衰老治疗糖尿病微血管病变的药物进行综述，为防治糖尿病微血管病变提供新的研究思路。

关键词: 糖尿病微血管病变, 细胞衰老, 机制, 药物

Abstract:

Diabetic microangiopathy is the earliest and most common complication of diabetes mellitus, which is characterised by impaired endothelial function of the microvessels, basement membrane thickening and microthrombosis, involving the kidneys, retina and nerves, and it is also a key factor leading to the decline in the patient’s quality of life and the shortening of life expectancy. In recent years, clinical and experimental studies have found that cellular senescence is a major risk factor for this type of disease, and cellular senescence is an irreversible state of cell cycle arrest, which participates in a variety of physiopathological processes affecting the occurrence and development of diabetic microangiopathy. This article provides a review of the mechanism of cellular senescence in the process of diabetic microangiopathy and the drugs that target cellular senescence for the treatment of diabetic microangiopathy to provide new research ideas for the prevention and treatment of diabetic microangiopathy.

Key words: diabetic microangiopathy, cellular senescence, mechanisms, drugs

中图分类号:

李金菊, 杨浩, 阮诺冰, 许奇, 毕正, 李瑜璠, 王帆竞, 林逸轩, 方朝晖. 糖尿病微血管病变中的细胞衰老及治疗药物研究进展[J]. 中国临床药理学与治疗学, 2026, 31(4): 509-516.

Jinju LI, Hao YANG, Nuobing RUAN, Qi XU, Zheng BI, Yufan LI, Fanjing WANG, Yixuan LIN, Zhaohui FANG. Research progress on cellular senescence and therapeutic drugs in diabetic microvascular complications[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(4): 509-516.

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糖尿病微血管病变中的细胞衰老及治疗药物研究进展

Research progress on cellular senescence and therapeutic drugs in diabetic microvascular complications

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