Role of Th17 cells in acne pathogenesis and the correlation with severity of acne

doi:10.12092/j.issn.1009-2501.2018.01.016

Abstract

Abstract:

AIM: To investigate the mechanism of Th17 cells in acne development and its correlation with severity. METHODS: One hundred and thirty six cases were divided into control, mild, moderate and severe acne group according to the Pillsbury method. The expression levels of IL-17, IL-23, IL-6 and TGF-beta1 in serum were detected by ELISA. RORγt mRNA and IL-17 mRNA expression levels were detected by RT-PCR. RESULTS: The levels of IL-17 and IL-23 in serum of patients with moderate to severe acne were significantly higher than those of the control and mild acne groups (P<0.05). The levels of IL-6 and TGF-beta1 in moderate and severe acne groups were significantly higher than those of control group (P<0.05). There was no significant difference in the expression of IL-6 and TGF-beta1 between mild and moderate acne groups (P>0.05). In addition, the expressions of IL-17 mRNA and RORγt mRNA from mild to severe groups were significantly different from control group (P<0.05). And there was significant difference between the three groups (P<0.05). CONCLUSION: Th17 cells have a cascade effect in mild, moderate and severe acne groups, which can provide a new target for future treatment of severe acne.

Key words: Th17 cells, acne, IL-17, IL-23, IL-6, TGF-β1, RORγt

CLC Number:

R751.05

LU Wei, ZHOU Bingrong,TANG Yi, FAN Yibin, TAO Xiaohua. Role of Th17 cells in acne pathogenesis and the correlation with severity of acne[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(1): 83-87.

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