Effects of coenzyme Q10 chaperone drinks on femur and ulna in the mild aging mice

doi:10.12092/j.issn.1009-2501.2018.03.008

Abstract

Abstract:

AIM: To investigate the effect of coenzyme Q10 chaperone drinks on femur and ulna in the mild aging mice with Micro CT technology and bone composition analysis method. METHODS: Eight-month-old SPF grade Kunming mice, both male and female, were randomly into normal saline group (NS), coenzyme Q10 Group (Q10), coenzyme Q10 chaperone drinks group (QC). After 10 weeks, the right femur was performed on Micro CT, and the left ulna bone was collected for detecting the content of Ca, Mg and Hyp. RESULTS: After giving coenzyme Q10 chaperone drinks, the body weight decreased in mice. Compared with NS group, QC group had a significant decrease in the Hyp content, SMI, and increased significantly in Ca, Mg content, BV/TV, Density and Conn-Dens. Compared with Q10 group, QC group had a significant decrease in the Hyp content, and increased significantly in Ca, Mg content. Micro CT three-dimensional image showed that the trabecular bone increased significanty, the number increased, and the degree of tightness was better, the continuity was restored in QC group, while compared with the NS group, the trabecular bone quantity, thickness, and distribution were significantly improved. CONCLUSION: Coenzyme Q10 chaperone drinks can improve the bone mass in the mild aging mice, suggesting a good prospects of the components in anti-osteoporosis application.

Key words: coenzyme Q10, mild aging mice, Micro CT, bone composition analysis

CLC Number:

R965.2

LV Simin, HUANG Zhirong, YU Qiong, SUN Jinying, CUI Liao, WU Tie. Effects of coenzyme Q10 chaperone drinks on femur and ulna in the mild aging mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(3): 290-295.

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