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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2018, Vol. 23 ›› Issue (8): 916-921.doi: 10.12092/j.issn.1009-2501.2018.08.013

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Analgesia effect of small amount of buprenorphine on children undergoing laparoscopic hernia repair under general anesthesia

YING Haifeng, ZHANG Weiping, YOU Kuangzhang, CHEN Lingyang   

  1. Department of Anesthesiology, Zhejiang Taizhou Hospital, Linhai 317000, Zhejiang, China
  • Received:2018-02-26 Revised:2018-06-09 Online:2018-08-26 Published:2018-08-28

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Abstract:

AIM: To investigate the analgesia effect of small amount of buprenorphine on children undergoing laparoscopic hernia repair under general anesthesia. METHODS: From January 2016 to June 2017, sixty-two children undergoing laparoscopic hernia operation under general anesthesia in our hospital were randomly divided into control group and study group, with 31 cases in each group. The study group received buprenorphine 3 μg/kg on the induction of anesthesia, and the control group received equal amount of saline. Inflammatory cytokines, immune function were detected at Pre infusion (T0), postoperative 6 h (T1), 12 h (T2), and 24 h (T3), and pain and sedation scores as well as the clinical index and agitation classification were observed and compared after the operation. RESULTS: Compared with T0, levels of serum CRP, TNF-α and Cor in the control group increased at T1, T2, and T3; levels of CD4+, CD8+, CD4+/CD8+ decreased; levels of serum CRP, TNF-α and Cor in the study group increased at T2, and T3; levels of CD4+, CD8+,CD4+/CD8+ decreased (P＜0.05). Compared with the control group, levels of serum CRP, TNF-α and Cor in the study group at T1, T2, and T3 were lower; levels of CD4+, CD8+, CD4+/CD8+ were higher (P＜0.05). Compared with T1, RASS scores in the control group decreased at T2 and T3; pain scores and RASS scores in the study group decreased at T2, T3. Compared with the control group, pain scores and RASS scores in the study group at T2, T3 were lower (P＜0.05), the cough response and agitation scores in the study group were lower than those of the control group (P＜0.05). CONCLUSION: Small amount of buprenorphine has a good analgesic and sedative effects on pediatric laparoscopic hernia repair under general anesthesia by reducing inflammation and improving immune function.

Key words: buprenorphine, children, pediatric laparoscopic hernia repair under general anesthesia, abirritation

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