Diagnostic value of thyroid function in pregnant women with pre-eclampsia

doi:10.12092/j.issn.1009-2501.2019.01.012

Abstract

Abstract:

AIM: To investigate the diagnostic value of thyroid function in pregnant women with pre-eclampsia (PE) so as to provide reference for the diagnosis and early treatment of pregnant women with PE. METHODS: Forty-one patients with PE in our hospital were selected from Mar.2015 to Feb.2017 for the observation group, 29 healthy pregnant women who were participate in physical examination at the same time were selected for the control group. The levels of free thyroxine (FT4), thyroid stimulating hormone (TSH) and thyroid peroxidase autoantibody (TPOAb) were compared between groups. ROC curve was used to analyze the diagnostic value of FT4, TSH, TPOAb detection and the joint detection of three indicators for PE, and the positive and negative prediction rate, sensitivity, specific, consistency and area under curve (AUC) of the detection results were compared. RESULTS: The level of TSH and TPOAb in observation group were significantly higher than those in control group (P<0.05), and the level of FT4 in observation group was significantly lower than that in control group (P<0.05). The positive predictive value of FT4, TSH, TPOAb detection and joint detection were 0.871, 0.917, 0.848 and 0.923, the negative predictive value were 0.641, 0.765, 0.649 and 0.839, the sensitivity were 0.659, 0.805, 0.683 and 0.878, the specificity were 0.862, 0.897, 0.828 and 0.897, the value of Kappa were 0.496, 0.684, 0.491 and 0.767, the AUC were 0.620, 0.706, 0.675 and 0.775. The AUC of joint detection is significantly higher than FT4 level detection, TSH level detection and TPOAb level detection (P<0.05). CONCLUSION: Each index detection of thyroid function has high diagnostic value in pregnant women with PE, and the highest diagnostic value of PE is joint detection.

Key words: pregnant, thyroid function, pre-eclampsia, diagnostic value

CLC Number:

R714

CAI Hairui，CHENG Shuqing，LIU Xijuan,CHEN Aner. Diagnostic value of thyroid function in pregnant women with pre-eclampsia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(1): 71-76.

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