Regulation of REM sleep: Basic mechanisms and clinical drugs

doi:10.12092/j.issn.1009-2501.2020.02.015

Abstract

Abstract: To explore the mechanism of rapid eye movement (REM) sleep regulation and the drugs that affect it. This article summarizes the relevant nucleuses regulating REM sleep in the pontine, medulla, and hypothalamus starting from the neural circuit that regulates REM sleep. Drugs that affect REM sleep, such as selective norepinephrine reuptake inhibitors and selective 5-hydroxytryptamine (5-HT) reuptake inhibitors, etc. The mechanism of action can be summarized as reducing the degradation of norepinephrine and 5-HT of synaptic sites, prolonging the action time of neurotransmitters, reducing the reuptake of presynaptic membrane, prolonging the action time of transmitters in the synaptic space, and relatively increasing norepinephrine and 5-HT neurons excitement.

Key words: antidepressants, rapid eye movement sleep, neural circuits

CLC Number:

R969
Q428

SUN Xiao, YANG Surong, LI Shanqun, WANG Yiqun. Regulation of REM sleep: Basic mechanisms and clinical drugs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(2): 214-220.

References

［1］Zhang Z, Liu WY, Diao YP, et al. Superior colliculus GABAergic neurons are essential for acute dark induction of wakefulness in mice［J］. Curr Biol, 2019, 29(4): 637-644,e633.
［2］Zhang Z, Wang HJ, Wang DR, et al. Red light at intensities above 10 lx alters sleep-wake behavior in mice ［J］. Light Sci Appl, 2017, 6(5): e16231.
［3］Wang YQ, Li R, Wang DR, et al. Adenosine A2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents ［J］. Brain Struct Funct, 2017, 222(3): 1351-1366.
［4］Roffwarg HP, Muzio JN, Dement WC. Ontogenetic development of the human sleep-dream cycle ［J］. Science, 1966, 152(3722): 604-619.
［5］Cox J, Pinto L, Dan Y. Calcium imaging of sleep-wake related neuronal activity in the dorsal pons ［J］. Nat Commun, 2016, 7: 10763.
［6］Datta S. Cellular basis of pontine ponto-geniculo-occipital wave generation and modulation ［J］. Cell Mol Neurobiol, 1997, 17(3): 341-365.
［7］Chen KS, Xu M, Zhang Z, et al. A hypothalamic switch for REM and non-REM sleep［J］. Neuron, 2018, 97(5): 1168-1176,e1164.
［8］Jouvet M. The states of sleep ［J］. Sci Am, 1967, 216: 62-68.
［9］Peever J, Fuller PM. The biology of REM sleep［J］. Curr Biol, 2017, 27(22): R1237-R1248.
［10］Xi MC, Morales FR, Chase MH. The motor inhibitory system operating during active sleep is tonically suppressed by GABAergic mechanisms during other states ［J］. J Neurophysiol, 2001, 86(4): 1908-1915.
［11］Bridi MCD, Aton SJ, Seibt J, et al. Rapid eye movement sleep promotes cortical plasticity in the developing brain［J］. Sci Adv, 2015, 1(6): e1500105. doi: 10.1126/sciadv.1500105.
［12］Vetrivelan R, Kong D, Ferrari LL, et al. Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice［J］. Neurosci, 2016, 336: 102-113.
［13］Weber F, Chung S, Beier KT, et al. Control of REM sleep by ventral medulla GABAergic neurons ［J］. Nature, 2015, 526(7573): 435-438.
［14］Boyce R, Glasgow SD, Williams S, et al. Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation［J］. Science, 2016, 352(6287): 812-816. doi: 10.1126/science.aad5252.
［15］Buzsaki G. Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning ［J］. Hippocampus, 2015, 25(10): 1073-1188.
［16］Kroeger D, Ferrari LL, Petit G, et al. Cholinergic, glutamatergic, and GABAergic neurons of the pedunculopontine tegmental nucleus have distinct effects on sleep/wake behavior in mice ［J］. J Neurosci, 2017, 37(5): 1352-1366.
［17］Kubin L. Carbachol models of REM sleep: recent developments and new directions ［J］. Arch Ital Biol, 2001, 139(1/2): 147-168.
［18］Krenzer M, Anaclet C, Vetrivelan R, et al. Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia［J］. PLoS One, 2011, 6(10): e24998.
［19］Crochet S, Sakai K. Effects of microdialysis application of monoamines on the EEG and behavioural states in the cat mesopontine tegmentum ［J］. Eur J Neurosci, 1999, 11(10): 3738-3752.
［20］Luebke JI, Greene RW, Semba K, et al. Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro ［J］. Proc Natl Acad Sci U S A, 1992, 89(2): 743-747.
［21］Yang SR, Hu ZZ, Luo YJ, et al. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep ［J］. PLoS Biol, 2018, 16(4): e2002909.
［22］Boissard R, Fort P, Gervasoni D, et al. Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset［J］. Eur J Neurosci, 2003, 18(6): 1627-1639.
［23］Weber F, Hoang Do JP, Chung S, et al. Regulation of REM and non-REM sleep by periaqueductal GABAergic neurons［J］. Nat Commun, 2018, 9(1): 354.
［24］Luppi PH, Clement O, Sapin E, et al. Brainstem mechanisms of paradoxical (REM) sleep generation ［J］. Pflugers Arch, 2012, 463(1): 43-52.
［25］Goutagny R, Luppi PH, Salvert D, et al. Role of the dorsal paragigantocellular reticular nucleus in paradoxical (rapid eye movement) sleep generation: a combined electrophysiological and anatomical study in the rat ［J］. Neuroscience, 2008, 152(3): 849-857.
［26］Sherin JE, Shiromani PJ, McCarley RW, et al. Activation of ventrolateral preoptic neurons during sleep ［J］. Science, 1996, 271(5246): 216-219.
［27］Hassani OK, Lee MG, Jones BE. Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle ［J］. PNAS, 2009, 106(7): 2418-2422.
［28］Izawa S, Miyazaki T, Mukai Y, et al. REM sleep-active MCH neurons are involved in forgetting hippocampusdependent memories ［J］. Science, 2019, 365(6459):1308-1313. doi: 10.1126/science. aax9238.
［29］Gillin JC, David RJW, Snyder F. The relationship between changes in REM sleep and clinical improvement in depressed patients treated with amitriptyline ［J］. Psychopharmacology, 1978, 59(3): 267-272.
［30］Steiger A. Effects of clomipramine on sleep eeg and nocturnal penile tumescence-a long-term study in a healthy man ［J］. J Clin Psychopharmacol, 1988, 8(5): 349-354.
［31］Landolt HP, de Boer LP. Effect of chronic phenelzine treatment on REM sleep: report of three patients ［J］. Neuropsychopharmacol, 2001, 25(5 Suppl): S63-S67.
［32］Jindal RD, Fasiczka AL, Himmelhoch JM, et al. Effects of tranylcypromine on the sleep of patients with anergic bipolar depression ［J］. Psychopharmacol Bull, 2003, 37(3): 118-126.
［33］Taranto-Montemurro L, Edwards BA, Sands SA, et al. Desipramine increases genioglossus activity and reduces upper airway collapsibility during non-rem sleep in healthy subjects ［J］. Am J Respir Crit Care Med, 2016, 194(7): 878-885.
［34］Shipley JE, Kupfer DJ, Griffin SJ, et al. Comparison of effects of desipramine and amitriptyline on EEG sleep of depressed patients ［J］. Psychopharmacology (Berl), 1985, 85(1): 14-22.
［35］Taranto-Montemurro L, Sands SA, Edwards BA, et al. Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation ［J］. Eur Respir J, 2016, 48(5): 1340-1350.
［36］Pinkerton JV, Joffe H, Kazempour K, et al. Low-dose paroxetine (7.5 mg) improves sleep in women with vasomotor symptoms associated with menopause［J］. Menopause, 2015, 22(1): 50-58.
［37］Isa Kara M, Ertas ET, Ozen E, et al. BiteStrip analysis of the effect of fluoxetine and paroxetine on sleep bruxism［J］. Arch Oral Biol, 2017, 80: 69-74.
［38］Wang YQ, Tu ZC, Xu XY, et al. Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats ［J］. J Neurochem, 2012, 120(2): 314-324.
［39］Fuchs T, Siegel JJ, Burgdorf J, et al. A selective serotonin reuptake inhibitor reduces REM sleep in the homing pigeon ［J］. Physiol Behav, 2006, 87(3): 575-581.
［40］Staner L, Kerkhofs M, Detroux D, et al. Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: a double-blind randomized trial in major depression ［J］. Sleep, 1995, 18(6): 470-477.
［41］Kerkhofs M, Rielaert C, de Maertelaer V, et al. Fluoxetine in major depression: efficacy, safety and effects on sleep polygraphic variables ［J］. Int Clin Psychopharmacol, 1990, 5(4): 253-260.
［42］Shipley JE, Kupfer DJ, Dealy RS, et al. Differential effects of amitriptyline and of zimelidine on the sleep electroencephalogram of depressed patients［J］. Clin Pharmacol Ther, 1984, 36(2): 251-259.
［43］Rahimzadeh P, Imani F, Nafissi N, et al. Comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors［J］. Cancer Manag Res, 2018, 10: 4831-4837.
［44］Davari-Tanha F, Soleymani-Farsani M, Asadi M, et al. Comparison of citalopram and venlafaxine's role in treating sleep disturbances in menopausal women, a randomized, double-blind, placebo-controlled trial［J］. Arch Gynecol Obstet, 2016, 293(5): 1007-1013.
［45］Tan L, Zhou J, Yang L, et al. Duloxetine-induced rapid eye movement sleep behavior disorder: a case report ［J］. BMC Psychiatry, 2017, 17(1): 372.
［46］Luthringer R, Toussaint M, Schaltenbrand N, et al. A double-blind, placebo-controlled evaluation of the effects of orally administered venlafaxine on sleep in inpatients with major depression ［J］. Psychopharmacol Bull, 1996, 32(4): 637-646.
［47］Sahin OS, Malas FU. Duloxetine-induced sleep bruxism in fibromyalgia successfully treated with amitriptyline ［J］. Acta Reumatol Port, 2015, 40(4): 391-392.
［48］Mayers AG, Baldwin DS. Antidepressants and their effect on sleep［J］. Hum Psychopharmacol, 2005, 20(8): 533-559.
［49］Steiger A, von Bardeleben U, Guldner J, et al. The sleep EEG and nocturnal hormonal secretion studies on changes during the course of depression and on effects of CNS-active drugs ［J］. Prog Neuropsychopharmacol Biol Psychiatry, 1993, 17(1): 125-137.
［50］Schredl M, Berger M, Riemann D. The effect of trimipramine on dream recall and dream emotions in depressive outpatients ［J］. Psychiatry Res, 2009, 167(3): 279-286.
［51］Tan SM, Wan YM. Pramipexole in the treatment of REM sleep behaviour disorder: A critical review ［J］. Psychiatry Res, 2016, 243: 365-372.

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[4]	ZHONG Zhiyong, TAO Jiong, WANG Xianglan, HAN Hongying, LI Lingjiang. Treatment of major depression with short-term MECT in addition to antidepressants: its effects on clinical efficacy and cognitive function [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 179-183.
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