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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2020, Vol. 25 ›› Issue (3): 317-322.doi: 10.12092/j.issn.1009-2501.2020.03.012

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Effects of low-dose baclofen adjuvant therapy on patients with trigeminal neuralgia and its effects on inflammatory factors and oxidative stress

PI Zhibing 1, YANG Xuezhi 2, PENG Yu 1, ZHANG Junkai 1, ZHANG Lei 1, LIN Hai 1   

  1. 1 Department of Pain Treatment, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China;  2 Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  • Received:2019-08-09 Revised:2019-11-14 Online:2020-03-26 Published:2020-04-13

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Abstract: AIM: To study the effect of low-dose baclofen on inflammatory factors and oxidative stress in patients with trigeminal neuralgia. METHODS: A total of 112 patients with trigeminal neuralgia treated in our hospital from Jan. 2017 to Jan. 2019 were selected as the subjects; they were divided into test group (n=56) and control group (n=56) according to random number table method. The control group was treated with oxcarbazepine, while the test group was treated with low-dose baclofen on the basis of the control group; the clinical total effective rate, visual analogue scale (VAS), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels and the incidence of adverse reactions were compared between the two groups. RESULTS:The clinical total effective rate of the test group was significantly higher than that of the control group (P<0.05); the VAS score of the two groups was significantly lower than that before treatment (P<0.05), and the VAS score of the test group was significantly lower than that of the control group (P<0.05); the levels of TNF-α, IL-6 and in the two groups were significantly lower than those before treatment (P<0.05), and the levels of TNF-α, IL-6 and in the test group were significantly lower than those in the control group (P<0.05); the levels of MDA in the two groups were significantly lower than those before treatment (P<0.05), SOD and GSH-Px were significantly higher than those before treatment (P<0.05), and the levels of MDA in the test group were significantly lower than those in the control group (P<0.05), while the levels of SOD and GSH-Px were significantly higher than those in the control group (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). CONCLUSION:Low-dose baclofen adjuvant therapy has good clinical efficacy for patients with trigeminal neuralgia, which can effectively relieve pain, reduce inflammation and oxidative stress.

Key words: baclofen, oxcarbazepine, trigeminal nerve, inflammatory factors, oxidative stress reaction

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