Neutrophil extracellular traps and its role in gouty diseases

doi:10.12092/j.issn.1009-2501.2021.10.009

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2021, Vol. 26 ›› Issue (10): 1167-1173.doi: 10.12092/j.issn.1009-2501.2021.10.009

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Neutrophil extracellular traps and its role in gouty diseases

YI Hong¹, GU Bing¹, CHEN Yunian¹, LI Huanan²

1College of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi, China

Received:2021-03-23 Revised:2021-08-13 Online:2021-10-26 Published:2021-11-02
Contact: Bing GU E-mail:bguemory@hotmail.com

Abstract

Abstract: Neutrophil extracellular traps (NETs) are an important part of the innate immunity. They are mainly involved in the occurrence of gout disease through NADPH oxidase 2-dependent pathways and it is related to the spontaneous remission of gouty arthritis and the formation of tophi. These pathological features can be analyzed by methods such as electron microscopy and immunohistochemical staining. In order to further explore the molecular mechanism of NETs and discover potential drug targets for gouty arthritis, this article summarizes its role in gouty diseases and related detection techniques.

Key words: neutrophil extracellular traps, gouty arthritis, spontaneous remission, tophi, molecular mechanism, drug targets

CLC Number:

YI Hong, GU Bing, CHEN Yunian, LI Huanan. Neutrophil extracellular traps and its role in gouty diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(10): 1167-1173.

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Neutrophil extracellular traps and its role in gouty diseases

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