Abstract: Hydrogen sulfide (H2S), a colorless gas with a strong odor of rotten eggs, is an important biological signaling molecule, which is produced in vivo through enzyme-catalyzed and non-enzymatic pathways. Physiological levels of H2S have systemic antioxidant, anti-inflammatory, regulating apoptosis, dilating blood vessels, lowering blood pressure, neuroprotective effects, and prevent bone damage. H2S plays an important role in tissue repair, which is of great value for clinical treatments. In this paper, the common repair and regeneration functions and mechanisms of hydrogen sulfide in tissue damage will be reviewed, which will be helpful to understand the role of H2S in vivo and the development of new drugs.

Key words: hydrogen sulfide, tissue damage, repair and regeneration