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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2022, Vol. 27 ›› Issue (10): 1171-1181.doi: 10.12092/j.issn.1009-2501.2022.10.012

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Mechanism of action of bile acid metabolism in regulating inflammatory bowel disease and the research and development of drugs

DUAN Ruixiao 1,2,3, ZHAO Yifan 1,2,3, YE Yongjuan 1,2,3, LIU Min 2,3, LI Qiang 2,3, ZHOU Yongning 2,3   

  1. 1 The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu, China; 2 The First Hospital of Lanzhou University, Department of Gastroenterology, Lanzhou 730000, Gansu, China; 3 The First Hospital of Lanzhou University, Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China
  • Received:2022-06-23 Revised:2022-10-12 Online:2022-10-27 Published:2022-11-14

Abstract: Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal inflammatory disease with an increasing incidence and non-fatal disease burden worldwide. The etiology of IBD is complex, and the pathogenesis has not been completely clarified. Bile acids (BAs) are the main components of bile, which can participate in the occurrence and development of IBD by binding to bile acid receptors and regulating intestinal flora. This article focuses on the mechanism of BAs metabolism in the pathogenesis of IBD, and the research and development progress of drugs based on BAs and their related targets, so as to lay a foundation for the prevention, treatment and prognosis of IBD in the future.

Key words: inflammatory bowel disease, bile acid, bile acid receptors, gastrointestinal microbiome, targeted drugs

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