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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2023, Vol. 28 ›› Issue (5): 572-577.doi: 10.12092/j.issn.1009-2501.2023.05.012

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Effects and mechanism of traditional Chinese medicine injection in prevention and treatment of cardiotoxicity induced by antineoplastic drugs

LI Yanyang1,2,3,4, WANG Yunjiao5, LV Shichao5   

  1. 1Department of Integrated Traditional & Western Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China; 2National Clinical Research Center for Cancer, Tianjin 300060, China; 3Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China; 4Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China; 5Department of Geratology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
  • Received:2022-12-02 Revised:2023-04-25 Online:2023-05-26 Published:2023-06-08

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Abstract:

Traditional Chinese medicine injections for the prevention and treatment of cardiotoxicity of antineoplastic drugs was summarized, including Shengmai injection, Shenmai injection, Shenfu injection, Shenqi Fuzheng injection, Kangai injection, Huangqi injection, Xinmailong injection, Danhong injection, Danshen injection, Honghua injection, Kushen injection, Cinobufacin injection and Yinxingdamo injection. The mechanism of effect mainly includes inhibition of lipid peroxidation, reduction of calcium overload and anti-cardiomyocyte apoptosis, which provides the basis for the prevention and treatment of cardiotoxicity of anti-tumor drugs by traditional Chinese medicine.

Key words: malignant tumor, oncocardiology, cardiotoxicity, traditional Chinese medicine injection

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