Obstructive sleep apnea is caused by repeated apnea and/or hypopnea during sleep, which leads to chronic intermittent hypoxia with hypercapnia and sleep structure disorder, and then causes damage to systemic organs. Recent studies have found that in addition to the abnormal structure of the upper airway, the dysfunction of the pharyngeal dilator muscle and the instability of the upper airway are also prone to cause upper airway stenosis, and are related to the withdrawal of norepinephrine and the increase of acetylcholine during sleep. The combined use of norepinephrine reuptake inhibitor and muscarinic can reduce the severity of OSA by increasing genioglossus activity and improving airway stability, with good safety.