The treatment of multidrug-resistant gram-negative bacterial infections has become a challenge in today's healthcare field, and time-to-event data analysis has shown significant value in clinical prognostic studies of critically ill patients. This study comprehensively reviewed the results of the application of time-to-event analysis in clinical studies of anti- multidrug-resistant gram-negative bacterial drugs, aiming to provide a scientific basis for the optimization of therapeutic strategies and prognostic assessment of multidrug-resistant gram-negative bacterial infections, and to promote the widespread application of time-to-event analysis methods in similar studies.