Abstract: Aim To study the influence of prazosin hydrochloride on plasma digoxin levels when pra-zosin hydrochloride was added after administration of single dose or multiple doses of digoxin. Methods After po 20 μg/kg of digoxin with or without addition 150 μg/kg of prazosin hy-drochoride, the rabbit plasma digoxin levels were monitored by TDX.T-test was used to e-valuate the difference between the plasma digoxin levels after prazosin hydrochloride was added or not. Results The absorption course and elimination course of digoxin were prolonged when single dose of digoxin was given, and after multiple doses of digoxin, the steady state concentrations of digoxin were significantly raised when single dose of prazosin hydrochloride was given 6h later. Conclusion The plasma digoxin levels should be adjusted individually for the patients who use digoxin combined with prazosin chronically.

Key words: digoxin ;prazosin hydrochloride ;plasma lovel ;TDX