Abstract: Aim To evaluate the relative bioavailability of two kinds of acyclovir tablets manufactured by Xian Ju or Li Zhu pharmaceutical company. Methods Nine normal volunteers were included in a two-way cross-over study design. Blood samples were taken after a single oral dose ad-ministration of acyclovir tablets of 400mg and serum acyclovir concentration was determined by HPLC. Results The mean values of bioavailability parameters for Xian Ju product were: T =1.6h, AUC=3.496 μg/ml·h, C_max =1.011 μg/ml, MRT =3.27 h, respectively. For Li Zhu products, the parameters were:T =1.7h, AUC =3.693 μg/ml·h, C_max =0.997 μg/ml, MRT = 3.53h. Conclusion The two one-sided tests showed that two kinds of acyclovir tablets were bioequivalent.

Key words: acyclovir ; HPLC ; bioavailability