Abstract: Aim Theonset of complete blockade of brachial plexus andits sustained t imecaused by bupivacaine alone or by thedrug in combination with procaine and lidocaine werecompared.Methods 8086 patients received forearm and hand operations wererandomly dividedinto three groups, namely bupivacaine, bupivacaine plus procaine and bupivacaine plus lidocaine groups.Results Theonsett imeof complete block was shorter andits sustained period was long er in bupivacaine plus lidocaine group than theon ther groups (P<0.05 or P<0.01).When used with adrenlline, bupivacaine in any dosage w ould bring along er sustained period time(P<0.01). With theanesthetic dose decreased, there was a drop in theonsettimeof complete blo ck and thesustained period.Conclusion All theanesthetic methods could be usedin upperlimb's operations in patients who have different pathogenies, phy siques and operative times.

Key words: brachial plexus blockade, bupivacaine, procaine, lido caine