Effects of 17β-estradiol on isolated pig basilar arteries

Abstract

Abstract: Aim and Methods The relaxing and inhibitory effects of 17β-estradiol(E₂)on KCland 5-HT induced contraction of isolated pig basilar arteries were observed.Results After incubation with E₂(10^-5,10^-4.2mol/L),the phasic contract ion induced by KCl was inhibited in a concentration-dependent manner in artery rings(IC₅₀was10^-4.8mol/L),and the concentration effect curve generated by 5-HT was also inhibited (pD₂'was4.57).Conclusion E₂ has vasodilatory effect on isolated pig basilar arteries.

Key words: 17β-estradiol, isolated pig basilar arteries, 5-HT

CLC Number:

R977.12

CHU-Min, SUN De-Fu, LI Xiang-Duan. Effects of 17β-estradiol on isolated pig basilar arteries[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1998, 3(4): 272-274.

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Effects of 17β-estradiol on isolated pig basilar arteries

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