Abstract: Aim The method of preparing corneal collagen shield and its the rapeutic effect teating Herpes Simplex Kera tit is (HSK)w ere studied.Methods Collagen was extracted from sclera of pig.Using centrifugal method to make corneal collagen shield.After soaked with Aciclovir (ACV),the corneal collagen shields w ere used for treating HSK.Results The results indicate that in the grouPof corneal collagen shield soaked with ACV the average recover time of cornea was 9.45 days,in the grouPof instillation of ACV eye drops the average recover time was 14.36 days.The curerate and effective rate of the two groups were 90.63%、65.63% and 96.88%、81.25%(P<0.05).Conclusions The corneal collagen shield immersed with ACV will play an important role in HSK treatment.

Key words: corneal collagen shield, ACV, HSK