Abstract: Aim To compare the analgesic effect of the noneaddictive Propacetamol HCl with that of Dolantin (Pethidine HCl) on moderate postoperative pain. Methods 120 patients aged 18~75 years old were enrolled in this study, whose postoperative pain reached moderate to severe level after abdominal surgery, gynecol6gic surgery or orthopedic surgery. In the study group,2 g Propacetamol HCl was diluted and infused intravenously while at the same time 1.0 ml saline was injected intramuscularly; in the control group, 1.6 g mannitol as dummy drug was diluted and infused intravenously while at the same time 50 mg (1.0 ml) Dolantin was injected intramuscularly. Treatment was carried out randomly and double-blindly with the observation period of 6 hr in each case. Results & Discussion There was no obvious adverse reaction or erythra during the study period. After decoding as planed, it was shown that Propacetamol HCl and Pethidine HCl had the similar safety and efficacy. Since propacetamol HCl is none-addictive, it will have a future of wide application as analgesic for moderate postoperative pain.

Key words: none-addictive analgesic, Pro-Bufferin, propacetamol, postoperative pain