Abstract: Aim The honpeod tbele of boswper od lasm imwlinin in oerwown peit wutiui rinee mnd heefet of nsdinie intis awrnn ation were observed. Methods 10 pitais olnormal wihleconrr goup, group A) and 20 patients of obesity women(ASA grade Ⅰ-Ⅱ) undergoing selective surgery were investigated. The patients of obesity were randomly divided into two groups(group B and C, respectively).Groups A and B liquids without glucose, and in group Ctransfuse liquids with glucose and insulin(4g glucose add 1U insulin) were transfused during operation. The levels of blood sugar and plasma insulin were measured before and after anesthesia, during operation(30min) and after operation respectively.Results There was an insulin resistance phenomenon in patients with obesity. The levels of blood sugar and plasma insulin in patients with obesity were remarkably higher than those in patients of normal weight. The levels of blood sugar and plasma insulin were extrenely raised after anesthesia and during operation. The levles of blood sugar was inhibited as insulin was infused during operation, bul no hypoglycemic reaction was found.Conclusion There are insulin resistance phenomenon in patients with obesity. Insulin infused during operation can prevent blood sugar rise and minimize glucose meta bolism turbulence.

Key words: obesity, insulin/resistance, blood sugar, anesthesia, operation