Abstract: Aim To observe the effect of hemodialysis on pharmacokinetics of sparfloxacin in the patients contracting chronic renal failure. Methods Sparfloxacin concentrations in serum and urine of hemodialysis and non-dialysis patients were measured with a high performance liquid chromatography method after administration a single oral dose of 200 mg sparfloxacin. The pharmacokinetic parameters were computed with the program PKBP-N.Results The main pharmacokinetic parameters in hemodialysis group were T_1/2(ka)= (1.25士0.57) h,T_1/2(β)= (11.88士4.13) h,T_peak = (4. 18士0.78) h, C_max =(0.80+0.17) mg·L^-1 and AUC_0~∞= (6. 90土3.25) mg·h·L^-1,while in non-dialysis group were T_1/2(ka)= (1.12+0.42) h, T_1/2(β)= (15.93土5.20) h, T_peak =(3. 88土0.75) h, C_max= (0. 69+0.37) mg·L-1, AUC_0~∞= (10.05士4.13) mg·h·L^-1. The original sparfloxacin discharge rats in urine within 24 h were (8. 98士3.92)% and (10. 58土5. 64) % separately. Tr2q) and AUC in hemodialysis group were markedly lower:than in non-dialysis group (P<0. 05).Conclusion The pharmacokinetics of sparfloxacin in patients contracting chronic renal failure is not changed by hemodialysis.

Key words: sparfloxacin, pharmacokinetics, chronic renal failure, hemodialysis