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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2000, Vol. 5 ›› Issue (1): 10-12.

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Effect of anti-digoxin antiserum on endogenous digitalis-like factor and membrane ATPase activity in hypoxic injury myocardium1

KE Yong-Sheng, YANG Hao, YANG Ting, CHENG Guang-Hua, WANG You-Xia   

  1. Yijishan Hospital,Wannan Medical College,Wuhu 241001
  • Received:1999-12-10 Revised:1999-12-30 Online:2000-03-26 Published:2020-11-26
  • About author:Ke Yong sheng,male,associate professor,engaged in research ofcardiovascular diseases.
  • Supported by:
    1 Project supported by the Foundation of Anhui Education Com-mittee,No99jl0219

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Abstract: Aim To evaluate the protective effect of anti-digoxin antiserum on hypoxic injury my-ocardium and its mechanism.Methods It was observed that different concentration an-ti-digoxin antiserum effect on endogenous digitalis-like factor and cell membrane ATPase ac-tivity in hypoxic myocardium model.Results The level of endogenous digitalis-like factor was remarkably higher,cell membrane ATPase activity were remarkably lower in hypoxic group than those of normal group;anti-digoxin antiserum can resume membrane ATPase ac-tivity.Conclusion Rise of endogenous digitalis-like factor was basic of molecular biology of myocardial damage during myocardial hypoxia.Anti-digoxin antiserum has lightened my-ocardial injury and has protective effect on hypoxic myocardium by against effect of endoge-nous digitalis-like factor.

Key words: myocardium, hypoxic injury, endogenous digitalis-like factor, Na+-K+-ATPase, Ca2+-ATPase, anti-digoxin antiserum

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