Abstract: Aim To observe the dysfunction of my ocardial nuclear calciumtransport in rat myocardial injury and effects of taurine on it.Methods The model of my ocardial damage was induced by subcutaneous injection of isoproterenol(ISO,5mg·kg^-1·d^-1).Myocardial nuclei were purified with Sucrose density cent rifuga tion and ident if iedzymolog ically.The activity of Ca²⁺-ATPase was measured zymolog ically and calcium uptake was assayed with⁴⁵Ca²⁺iso tope.Results Compared with the control,the Ca²⁺-ATPase activity of my ocardial nuclear in ischemia group was decreased by 18.1%(P<0.05),the nuclear⁴⁵Ca²⁺uptake was significant decreased and Vmax value was lowered by 54.6%.With the controlg roup Ca²⁺-A TPase activ ity and⁴⁵Ca²⁺uptake in the my ocardial nuclei of Taugroup showed nosignificant changes.Conclusion The above results indicated taurine has notable protective effects on dysfunction of nuclear calciumt ransport in rat my ocardium.

Key words: myocardial injury, Ca²⁺transport, nucleus, taurin