Abstract: Aim To study the effects of alumina,magnesia,and simethicone tabeton the secretionof gastric acid and pepsin activity in rats.Methods The pharmacodynamic indices were measured by the secretion of gastric acid and pepsin activity.Results and Conclusion Compared with the controlgroup,alumina,magnesia,and simethicone inhibited gastricacid and increased pH of gastric juice.A significant decrease occurred in pepsin activity after a doses of 180mg·kg^-1and 600mg·kg^-1(P<0.05 and P<0.01,respectively)and a positive relationship between decreased pepsin activity and doses of alumina,magnesia,and simethicone(r =0.987).There are no influence on secretion of gastricjuice.

Key words: alumina magnesia simethicone, gastric acid secret ion, pepsin activity