Abstract: Aim The release process of an anticancer agent,DOX-HAP in rabbit live r was observed.Methods DOX and DOX-HAP were separately injectoed into rabbit livers under the guide of Btypeultrasound.Dox concentrations in plasma and liver tissue of the rabbits in both groups were measured by fluorescent stectrophotometer and compared.Results The concentration of complex could existedin the liver tissue about 5 d(1 000 ng·g^-1)when it was given in a dose of 2mg·g^-1.At the 10 min the concentration in plasma would be reduced about 1/2 as compared with that in the control group.Conclusion sThe DOX-HAP complex not only could increase and insist in an effective concentration of DOX at the local injecting area of liver tissue,but also reduce its concerntration in the plasma.The refore,it could decrease the toxicity and side-effect of DOX.

Key words: doxorubicin(DOX), hydroxy patite(HAP), drug concentration