Abstract: Aim The effect of Methyl Polyg ly coside (MPG)on cardiachemody namics in experimental heart failurecats was studied.Methods Model of experimental heart failurewas establishedin anesthetized cats.MPG(100 mg·kg^-1, 200 mg·kg^-1, iv)was administered by intravenous infusion and cardiachemody namics parameters weremeasured by using polygraph and electromag netic f lowmeter.Results LVSP,±d p/d t max, CO, CI, LVWI and MAP wereobvio usly increased, LVEDP was decreased and TPVR was not markedly alteredin both low and high do se MPG group.HR was not obviously changedin low-dose group, butit was light ly quickenedin high-dose group.Conclusion MPG has the actions of enhancing myocardial contraction, improving my ocardial compliancyand left ventricularsy stolic and diostolic function andincreasing cardiacoutput and arterial blood pressurein heart failurecats caused by Pentobarbital sodium.These show MPG is beneficialtoreleasing heart failure.

Key words: methylpolyg lycoside, heart failure, hemodynamics