Abstract: Aim The effect of tetrandrine on TGF-β₁ mRNA expression in glomerulosclero sisrat was observed.Methods The rats were randomly divided into four groups, such as the normal control grouP(sham operative rat), glomerulosclerosis model group, tetrandrine grouPand amlodipine grouP.The expression of TGF-β₁ mRNA was analyzed by Northern blot hybridization.Results The expressions of TGF-β₁ mRNA in two treating groups were much lower than untreated model grouP.There were no difference between these two treating groups.Conclusion Tetrandrine can decrease the expression of TGF-β₁ mRNA in glomerulo sclerosis rat induced by unilateral renctomy plus adriamycin.

Key words: tetrandrine, transforming growth factor-β₁, glomerulosclerosis