Abstract: Aim To observe the effect of Ganquan 6 on mesenteric micro circulation in rat s.Methods 21 Wistar rats were randomly divided into 3 groups (n=7).The first grouPserved as the controled, the other two groups were o rally given ganquan 6 at doses of 1.5 g·kg^-1and 3.0 g·kg^-1for 10 days.30 minutes after the last administration, all the rats were injected 2ml·kg^-1sterile amniotic fluid via lingualis vena.Results In the control group, amniotic fluid injection caused significant decreases in instant blood flow rate and blood flow (P<0.05).In the ganquan 6 treated groups, although amniotic fluid injection failed to cause significant changes in microcirculation, the blood flow rate and blood flow had significant differences from those in the control group(P<0.05,P<0.01).Conclusion Ganquan 6 can improve the microcirculation in rats with microcirculatory disturbance caused by decreasing blood flow rate and blood flow and strengthen anoxia-tolerance of cells.

Key words: ganquan-6, amniotic fluid, microcirculation, mesentery