Abstract: Aim The bioequivalence of domestic nimodipine capsules and tablets in healthy volunteers was compared.Methods A single oral dose of capsule or tablet of 100 mg nimodipine was given to 18 healthy volunteers in a randomized crossover study.Plasma levels of the drue were determined with HPLC method.Results The plasma concentration-time curve fitted to the first order absorption,1-compartment open model.Their main pharmacoknietic parameters were C_max (56.4±16.9)μg·L^-1,t_1/2(ke) (2.08±0.42)h,t_peak (1.27±0.52) h ,AUC_0~9 (197.2±46.5)μg ·h^-1·L^-1.These was no statistically significant difference between the two products (P>0.05).The relative bioavailability of tested capsules to reference tablets was (99.3±13.1)%.Conclusion Both formulations are of bioequivalence.

Key words: nimodipine, HPLC, bioequivalence