Abstract: Aim To study pharmacokinetics and bioavailablity of domestic penicillin V dispersion tablet in healthy volunteers. Methods According to the crossover design, each volunteer in two groups was orally given a single dose (0.75 g) of domestic penicillin V dispersion tablet or imported penicillinV tablet alternately and the plasma concentrations were determined by RP-HPLC. The pharmacokinetic parameters were obtained by using ATPK program and calculated on the basis of open single compartment model. Results After a single oral dose (0.75 g), the t_1/2(ke) was (0.75 ±0.10) h and (0.70 ±0.14) h, the c_max was (8.44 ±2.40) mg·L^-1 and (8.75 ±3.04) mg·L^-1 at (0.56 ± 0.11) h and (0.63 ±0.17) h and AUC_0~4 was (8.44 ±2.40) mg·h·L^-1 and (8.75 ±3.04) mg·h·L^-1 for two formulations, respectively. Relative bioavailability of domestic penicillin V dispersion tablet was (90.50 ±8.84) %.Conclusion The result shows that the two formulations are bioequivalent.

Key words: penicillin V dispersion tablet, relative bioavilability, HPLC