Abstract: Aim To observe the increased effects of verapamil combined with NaHCO₃ by tumors arterial infusion in patients with solid malig nant.Methods Ninety-two patients were randomly assig ned to four groups. Group A was infused with anti-cancer agent s;group B with NaHCO₃ and anti-cancer agents;group C with NaHCO₃, IL-2, IFN-αand anti-cancer agents, and group D was given NaHCO₃, verapamil, I L-2, IFN-αand anti-cancer agents.The efficacy was evaluated after the aterial interventional chemotherapy (1 time/mon× 2) in group A, B, C and D.Applying Seldinger penetrating technique, the drugs were infused at some proper concentrations as follow s:5% SB 80 -100 ml, NS 30 ml, IL-2 400～600(×103) U, IFN-α1～3 (×103) U, verapamil 10 -15 mg, ADM 50-60 mg, DDP 100 mg or MMC 10 mg or DPT 50 mg, 5-Fu 1.0 -1.5, verapamil 5 -10 mg with in 15 min.Results Partial remission (PR) in group B was significantlyhig herthan that in group A;PR in group D was higher than those in group A, B and C.Conclusion Arterial infusion of NaHCO₃ combined with verapamil into malignanttumors can increase the efficacy of anti-cancer agents and IL-2, IFN-α.

Key words: NaHCO₃, adriamycin, mi tomycin, interleukin-2, interferon-α, verapamil, hgdroxy-camptothecine aterial infusion