Abstract: AIM: To study the linear relationship be-tween pharmacokinetic parameters and doses about potas-sium clavulanic acid (CAV)and amoxicillin (AMX). METHODS: 15 healthy male volunteers were randomly divided into 5 dose-groups.The plasma concentration of CAV and AMX was determined by high performance liq-uid chromatography (HPLC)method.The pharmacokinet-ic parameters obtained with 3p97 soft were regressed to corresponding dose. RESULTS: The regression equations of AUC and c_max to dose about CAV were Y =2.0895X +0.4438 (r =0.9915)and Y =0.9397X +0.1796 (r =0.9922), respectively. The regression equations of AUC and c_max to dose about AMX were Y =4.8795X + 2.4794(r =0.9988)and Y =1.7276X +1.4832 (r = 0.9935), respectively. CONCLUSION: There is good linear relationship between pharmacokinetic parameters and doses about CAV and AMX.

Key words: potassium clavulanic acid, amoxicillin, linear relationship, pharmacokinetics, HPLC