Transport mechanism of β-lactam antibiotics in intestine and kidney

Abstract

Abstract: Some transport systems are found both in intestine and kidney with functional and morphological similarities, such as peptide transport system, organic anion transport system, organic cation transport system, and P-glycoprotein-mediated transport system.All these transport systems participate in the transporting process of β- lactam antibiotics in different extent.It suggests that inhibitors of renal transport may also affect the drug absorption of the intestine.

Key words: pharmacology, review, β-lactam antibiotics, PEPT, OATs, OCTs, P-gP

CLC Number:

R978.1

ZHANG Xiu-Hong, SONG Jian-Guo. Transport mechanism of β-lactam antibiotics in intestine and kidney[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(3): 252-254.

References

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