Abstract: AIM: To study the protection and mechanism of compound Hippophae rhamnoides L.granule 2 (CHRG2) on focal cerebral ischemia-reperfusion in rats. METHODS: Focal cerebral ischemia-reperfusion model was made with suture-occluded method.The volume of cerebral infarction, the level of MDA in serum, the activities of SOD and GSH-Px in serum were measured.The behavior obstacles of rats were observed. RESULTS: After cerebral ischemia-reperfusion, the content of MDA in serum and the volume of cerebral infarction increased significantly, the activities of SOD, and GSH-Px decreased significantly.CHRG2 could effectively prevent these changes. CONCLUSION: CHRG2 shows the protection against ischemia-reperfusion injury, and the effect may be related to raising anti-peroxidation of the brain tissue.

Key words: pharmacology, Hippophae rhamnoides L, cerebral ischemia-reperfusion injury, SOD, MDA, GSH-Px