Study of quercatin reverse druy-resistance of leukemia cell in vitro1

Abstract

Abstract: AIM: To explore the effect of quercetin on resistance reversal and its mechanism. METHODS: Human erythroleukemic cell line K562 and its doxorubicin- resistant counterpart K562 A02 were used in the study.Cytotoxicity was assessed by MTT assay.P-gp expression was measured with flow cytometry. RESULTS: Quercetin of 10μmol·L ^-1had no effect on the multidrug resistance reversal and P-gp expression.However, quercetin of 20 μmol·L ^-1 could increase chemosensitivity of F562 A02 and decrease the P-gp expression. CONCLUSION: Quercetin can reverse drug-resistance of K562 A02 cell to Daunorubicin.

Key words: pharmacodynamics, quercetin, drug-resistance, K562 cell, flow cyntometry

CLC Number:

QIAO Xin-Hui, TANG Hui-Fang, SONG Lan, LONG Shi-Ying, ZHOU Di-Xian, LIU Si-Chun. Study of quercatin reverse druy-resistance of leukemia cell in vitro¹[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(3): 302-303.

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Study of quercatin reverse druy-resistance of leukemia cell in vitro¹

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