Efficacy of deproteinised calf blood extract in treatment of patients with peptic ulcer disease

Abstract

Abstract: AIM: To observe the efficacy of deproteinised calf blood extract (DCBE) in the treatment of patients with peptic ulcer disease. METHODS: 60 patients were randomly divided into two groups.Treating group (n =32) received DCBE (800 mg, qd) and famotidine (100 mg, bid) and control group (n =28) received famotidine (100 mg bid).These treatments lasted for four weeks.The efficacy was determined by gastroendoscopy. RESULTS: The ulcer healing rates were 78.1 % and 46.4 %for 2 wk, and 84.4 % and 71.4 % for 4 wk in treating group and control group, respectively. CONCLUSION: DCBE has a significant effect in the treatment of patients with peptic ulcer disease.

Key words: pharmacodynamics, deproteinised calf blood extract, famotidine, peptic ulcer

CLC Number:

R975
R969.4

CAI Ning, WANG Hong-Xin, YAN Fei, WANG Zhi-Yi, YU Xiang-Guo, TANG Yi-Chao. Efficacy of deproteinised calf blood extract in treatment of patients with peptic ulcer disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(3): 314-316.

[1]	WU Yujie, ZHAO Chengcheng, XI Qing. Evaluation of tegacycline regimens in treatment of gram-negative bacterial infections with Monte Carlo simulation [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(9): 1027-1033.
[2]	GU Yifei, CHU Nannan, HUANG Kai, QUE Linling, ZHANG Jisheng, XIANG Xuemei, HE Qing. Application and progress of pharmacodynamics study in bioequivalence evaluation of orally inhaled drug products [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 822-833.
[3]	ZHANG Jinhua, LIU Maobai, CAI Mingzhi, ZHENG Yingli, LAO Haiyan, XIANG Qian, DU Liping, ZHU Zhu, DONG Jing, ZUO Xiaocong, LI Xingang, SHANG Dewei, CHEN Bing, YE Yanrong, WANG Yuzhu, GAO Jianjun, ZHANG Jian, CHEN Wansheng, XIE Haitang, JIAO Zheng. Model informed precision dosing of warfarin: China expert consensus report (2022 version) [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(11): 1201-1212.
[4]	XU Liying, ZHANG Gaosong, HUANG Xiaomin, HUANG Jihan, WANG Shuhua. Clinical efficacy and modeling evaluation of He-wei-zhi-xie capsules in treating diarrhea patients [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(1): 47-55.
[5]	JIAO Zheng, LI Xingang, SHANG Dewei, DONG Jing, ZUO Xiaocong, CHEN Bing, LIU Jianmin, PAN Yan, ZHOU Tianyan, ZHANG Jing, LIU Dongyang, LI Lujin, FANG Yi, MA Guangli, DING Junjie, ZHAO Wei, CHEN Rui, XIANG Xiaoqiang, WANG Yuzhu, GAO Jianjun, XIE Haitang, HU Pei, ZHENG Qingshan. Model informed precision dosing: China expert consensus report [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(11): 1215-1228.
[6]	LI Wenchao, BAI Xiangrong, LI Xiaoling, JIANG Dechun. Population pharmacokinetics/pharmacodynamics of tigecycline in the treatment of different infectious diseases [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(11): 1265-1272.
[7]	XIANG Rongfeng, SUN Fengjun, XIONG Lirong, YU Mingjie, DAI Qing, CHEN Yongchuan. Pharmacokinetics and pharmacodynamics of (S)-pantoprazole sodium enteric-coated tablets in healthy subjects [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(8): 903-909.
[8]	LI Jian, YANG Jinbo, WANG Yuzhu. Applications of model-informed drug development (MIDD) on new drug research and development [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(1): 1-8.
[9]	MA Guangli, XU Ling, CHEN Rui, CHEN Yuancheng, ZHAO Wei, LIU Dongyang, JIAO Zheng, LI Jian, JI Shuangmin, LI Li, LI Liang, WANG Yuzhu, YANG Jinbo, WANG Yaning, SUN He, HU Pei, ZHENG Qingshan, LU Wei. General considerations of population pharmacokinetic/pharmacodynamic study in new drug development [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(11): 1201-1220.
[10]	LIAN Yanhong, JIANG Huifang, YUAN Xiaohong, ZHOU Huidan, XIE Kangjie, FANG Jun, JIN Xiaoju. Effects of neoadjuvant chemotherapy on the pharmacodynamics of rocuronium bromide in patients undergoing gastric cancer surgery [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(10): 1161-1164.
[11]	LI Jingjing, YU Yanxia, TANG Lian, ZHANG Jinkun, YU Qiang, SHANG Erning. Influence of clinical pharmaceutical care on medication compliance and treatment effect in Helicobacter pylori positive peptic ulcer outpatients [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(2): 199-204.
[12]	ZHANG Chao . Pharmacodynamic studies evaluation of voriconazole [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(1): 116-120.
[13]	WU Yonglei, WANG Dan, ZHANG Suiyang, WANG Ying, SUN Qin. Pharmacokinetics and pharmacodynamics of meropene administered by traditional prolonged infusion or optimized prolonged infusion in different tissues of septic rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(7): 767-774.
[14]	ZHU Wen-jing, CUI Wei-hua, WANG Shao-hua, ZHANG Yuan-yuan, GAO Ji-jun. Development of moxifloxacin in treating community-acquired pneumonia [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(5): 597-600.
[15]	YE Long-qiang, SHI Lin-hui, QIU Xiao-hui, JIN Yu-hong, CAI Ting. Pharmacodynamics of prolonged dosing regimens of four β-lactam antibiotics against severe infection [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(1): 51-55.

Efficacy of deproteinised calf blood extract in treatment of patients with peptic ulcer disease

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments