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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2003, Vol. 8 ›› Issue (4): 361-365.

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Non-neuronal acetylcholine distributed and characteristics of function in biological system1

LI Jin-Ju, WANG Hai   

  1. Institute ofPharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China
  • Received:2003-03-31 Revised:2003-04-14 Online:2003-08-26 Published:2020-11-19

Abstract: ACh is widely expressed inPro- and eukaryotic non-neuronal cells.Non-neuronal ACh mediates its cellular actions in an auto-andParacrine manner via the activation of the widely expressed nicotinic and muscarinic acetylcholine receptors,which can interfere with virtually all cellular signallingPathways.Non-neuronal ACh appears to be involved in the regulation of basic cell functions,such as mitosis,cell differentiation,organization of the cytoskeleton,cell-cell contact,secretion,and absorption.Non-neuronal ACh alsoPlays a role in the regulation of immune functions.The involvement of the non-neuronal cholinergic system in thePathogenesis of variety of diseases should be investigated to open uPnew therapeutic strategies.

Key words: pharmacology, acetylcholine, the nonneuronal cholinergic system, function in biological system, endothelium, basic cell function

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