Abstract: AIM: To establish a new method for calculating thePharmacokineticParameters of bi-compartmental drugs based on thePlasmalevel of the drug during the intravenous infusionPhase.METHODS: The novel method was based on the analysis of differential kinetics of thePlasmalevel before thePlasmalevel reaches the steady-state concentration of the bi-compartmental drug,which was administered by a constant rate of intravenous infusion.RESULTS: The new method could obtain the volume of the central andPeripheral compartments,as well as the kineticParameters between the two compartments of the drug in a simplified manner.The results of the simulation with a model drug administered by intravenous infusion indicatedPreferable methodological accuracy.CONCLUSIONS: A new method is characteristic of simplicity andPredictability forProcessing thePharmacokineticParameters of the bi-compartment drugs based on thePlasmalevels before the steady-state administered by intravenous infusion.

Key words: pharmacology, differential mathod, pharmacokinetics, bi-compartment, intravenous infusion