Abstract: AIM: To evaluate itsPharmacodynamic effects of zhi-chuan-ling(ZCL)oralliquor,a traditional Chinese medicinalPrescription,on asthma.METHODS: Asthma models of guineaPigs were established by aerosol inhalation of mixed solution of histamine and acetylcholine for the observation of effects of ZCL on thelatentPeriod of asthma attack.Some other indices were also investigated including the contraction of smooth muscle strips isolated from the trachea or intestinum ileum,and variations of the tracheal volume and the bronchotrachealPerfusion in guineaPigs.RESULTS: ZCL elongated thelatentPeriod of asthma attack induced by areol inhalation of mixed solution of histamine and acetylcholine,antagonized activities against the contraction of the trachea and intestinum ileum induced by histamine or acetlcholine,and increased the tracheal volume and the bronchotrachealPerfusion in gineaPigs in vitro.CONCLUSION: ZCL can reduce airway hyperresponsibility,relax bronchospasm,remit ventilation disturbance,and improve ventilatory function by its biologic activities against acetlcholin and histamine.

Key words: pharmacology, zhi-chuan-ling oralliquor, asthma, smooth muscle, tracheal volume, bronchotrachealPerfusion