Abstract: AIM: To investigate the effects and safe oflow molecular weight heparins(lMWH)in the treatment ofPatients with chronicPulmonary heart diseases(CPHD)at hypercoagulability state.METHODS: 65Patients were randomly assigned to treatment grouP(n =33)and control grouP(n =32).AllPatients were given routine treatments.ThePatients of treatment grouPwere hypodermically injected with 4 100~6 150 U oflMWHPer day for 7 days as a course.RESULTS: After 7 days of the treatments,thePatients of treatment grouPshowed better curative effect and significantly increase inPaO₂and AT-III and decrease inPaCO₂and FIB in comparison with thePatients in control grouP(P<0.05).CONCLUSION: LMWH is an effective agent in treatment ofPatients with CPHD.

Key words: pharmacodynamics, chronicPulmonary heart diseases, hypercoagulability state, low molecular weight heparins