Abstract: AIM: To study the curative effect andPartial mechanism of the kechuanningPowder on bronchial asthma.METHODS: ThePulmonary function,thelevel of serum IgE,and the clinical control rate ofPatients treated with the kechuanningPowder were observed.The inducing incubationPeriod of asthma attack,levels of nitric oxide(NO),and endothelin-1(ET-1)in bronchoalveolarlavage fluid(BALF)were also tested in asthma guineaPigs.RESULTS: KechuanningPowderwas effective on improvingPulmonary function and reducing the abnormal raise of IgE,and the clinical control rate was similar to that with budesonide inPatients with bronchial asthma.The study also showed the inducing incubationPeriods of asthma attack in kechuanningPowder grouPwere markedlylonger than those in asthma group.KechuanningPowder had a significantly inhibitory effect on increased NO and ET-1levels of BALF in asthma guineaPig.CONCLUSION: KechuanningPowder shows a better effect on bronchial asthma,which might be related to reduce thelevel of IgE,NO,and ET-1 in vivo.

Key words: pharmacodynamics, kechuanningPowder, bronchial asthma, pulmonary function, nitric oxide, endothelin-1, budesonide