Abstract: AIM: To compare genotypePolymorphism of cytochrome CYP2C19 between Chinese Meng subjects and Chinese Han subjects.METHODS: The genotypePolymorphism was analyzed byPCR-RFLP(Restriction FragmentlengthPolymorphism)in 74 subjects of healthy Chinese Han and 6 subjects of Chinese Meng.RE-SULTS: Of the 74 genotyped healthy subjects,31(41.9%)were homozygous for wildtype (wt/wt),9(12.2%)were homozygous for CYP2C19m1 and CYP2C19m2 (m1/m1 or m1/m2 or m2/m2),and 34(45.9%)were heterozygous for CYP2C19m1 or CYP2C19m2 (m1/wt or m2/wt).Among the 6 genotyped Chinese Meng,1 (16.7%)was homozygous for wildtype(wt/wt),2 (33.3%)were homozygous for mutant allele CYP2C19m1 and CYP2C19m2 (m1/m1 or m1/m2 or m2/m2),and 3(50.0%)were heterozygous for CYP2C19m1 or CYP2C19m2 (m1/wt or m2/wt);no homozygousgeno-type for CYP2C19m2(m2/m2)was found in this study.CONCLUSION: There is no statistical difference in oc-currence of wt/wt and m1/m1 between in 74 subjects of healthy Chinese Han and 6 subjects of Chinese Meng.

Key words: cytochrome, CYP2C19, genotype, poly-morphism