Abstract: AIM: To evaluate the efficacy of intracranial injection of the nerve growth factor (NGF) in treatment of patients with hypertensive cerebral hemorrhage after intracranial hemorrhage mini-invasive drainage.METHODS: 90 hypertentive cerebral hemorrhage patients after intracranial hemorrhage mini-invasive drainage were divided into three groups:Group A (n =30), patients were intracranial injected with 2 ml normal saline per day for 4 days, and then intracranial injected with 2 ml water per day for 10 days; Group B (n =30), patients were intracranial injected with 2 ml normal saline per day for 4 days, and then intracranial injected with 2 ml NGF per day for 10 days; Group C (n =30), patients were intracranial injected with 2 ml NGF per day for 4 days, and then intracranial injected with 2 ml NGF per day for 10 days. The curative effect was evaluated by neurological function scoring, ADL scoring and mortality after 1 month therapy.RESULTS: There was no significant difference on mortality in group A (13. 3 %), group B (10. 0 %) and group C (10. 0 %). The effective rates in group B (40 %) and group C (70 %) were higher than that in group A (20 %) (P<0. 05), and the total effective rate in group B (66. 67 %) and group C (80 %) were higher than that in group A (36. 67 %) (P<0. 05). Meanwhile, the values of ADL scoring were more significantly increased in group B and group C than that in group A.CONCLUSION: NGF can increase the clinical curative effect and decrease the disability rate in patients with hypertensive cerebral hemorrhage, and it can obviously improved the patient' s life quality. Furthermore, the effect of intracranial injection of NGF is marked.

Key words: mini-invasive drainage, hypertensive cerebral hemorrhage, nerve growth factor (NGF), curative effect evaluation