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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (11): 1217-1220.

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Characteristics of antinociceptive effects of choline in central nervous system in mice

SU Dong-Mei1, LIU Yue1, WANG Yue12, WANG Ru-Huan3, WANG Hai1   

  1. 1Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China;
    2Medicine College of Shandong University,Jinan 250012, Shandong, China;
    3Thadweik Academy of Medicine, Beijing 100850, Chirm
  • Received:2004-07-13 Revised:2004-08-24 Online:2004-11-26 Published:2020-11-19

Abstract: AIM: To investigate the characteristics of the antinociceptive effects of choline in central nervous system (CNS) in mice. METHODS: Hot-plate test (icv) was used to study the antinociceptive effects of cho-line, the influences of many antagonists on the antinoci-ceptive effects of choline were observed, the potential mechanisms underlying the antinociceptive effects of cho-line were discussed. RESULTS: With the administration of choline 90-120 μg per mouse, antinociceptive effects showed in a dose-dependent manner. MLA(50 μg per mouse), a-BTX(2 μg per mouse) and atropine(0.1 μg per mouse) significantly blocked the effect of choline; mecamylamine(5 μg per mouse) and naloxone(2 μg per mouse) failed to block choline-induced antinociception. CONCLUTION: Choline-induced antinociception is me-diated by α7-nAchR subtype, while mAchR seems to be related to choline-induced antinociception.

Key words: nAchR agonist, choline, α7-nAchR subtype, antinociceptive effect, hot-plate

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