Abstract: AIM: To study the bioequivalence be-tween flunarizine hydrochloride dispersible tablets and capsules in healthy volunteers. METHODS: A single dose of 20 mg flunarizine hydrochloride dispersible tablets and capsules were given to 20 healthy volunteers by a ran-domized,two way cross-over design. Plasma concentra-tions of flunarizine hydrochloride were determined by HPLC. RESULTS: The pharmacokinetic parameters after administration of flunarizine hydrochloride dispersible tablets and contrast flunarizine hydrochloride capsules (20 mg) were as follows: AUC_0-1, 424.27±74.01 and 410.25±72.56 μg·L^-1,C_67.02±14.89 and 67.45±15.68 μg·L^-1,T_max 2.90±0.42 and 2.98±0.47 h, and t_1/2ke9.73±3.15 and 8.89±3.08 h,respectively. The relative bioavailability of the flunaiizine hydrochloride tablets was (104.12±12.23)%. CONCLUSION: Two formations of flunarizine hydrochloride are bioequivalent.

Key words: flunarizine hydrochloride, HPLC, phar-macokinetics, bioavailability, dispersible tablets