Abstract: AIM: To compare the influence of salvia miltiorrhiza Bunge njection (SMBI) and salvia przewalskii Maxim injection (SPMI) on energy metabolism of acute brain lacking oxygen.METHODS: The whole brain lacking oxygen model was made by injecting NaNO₂ in mice and then wrote down the existent time of mice and detected the contents of Na⁺-K⁺-ATPase, Ca²⁺-ATPase and lactic acid (LD) in the brain.RESULTS: SMBI and SPMI both significantly lengthened the existent time of mice with the whole brain lacking oxygen, decreased the contents of LD and increased the activity of ATPase in mice.In increasing the activity of ATPase, the influence of SPMI was more than that of SMBI (P<0.05), but there was no significant difference between two injections in decreasing the contents of LD (P >0.05).CONCLUSION: SMBI and SPMI have distinctive protection on energy metabolism of acute brain lacking oxygen.Both of them can lengthen the existent of mice, reduce the contents of LD in brain and increase the activity of ATPase, but SPMI is more excellent than SMBI in increasing the activity of ATPase.

Key words: salvia miltiorrhiza Bunge injection(SMBI), salvia przewalskii Maxim injection (SPMI)acute brain lacking oxygen, Na⁺-K⁺-ATPase, Ca²⁺-ATPase, laitic acid